This is a comprehensive, chronological list of deaths that have occurred within FOX's Scream Queens.
As of Drain the Swamp, a total of 52 deaths have happened over the course of 22 episodes.
Deaths
| # (episode) | # (chronological) | Name | Episode | Cause of Death | Killer | On-Screen | Notes |
| 1 | 1 | Sophia Doyle | Pilot | Bled out from childbirth. (flashback) |
None (bleeding) | No | Death indirectly caused by her friends choosing to party over helping her; sets off a chain of events within KKT. |
| 2 | 5 | Agatha Bean | Head pushed into deep fryer, burning her face off. | Chanel Oberlin, Red Devil (Hester) | Yes | Hester turned the fryer on while it was supposed to be off for Chanel's prank. | |
| 3 | 6 | Sonya Herfmann | Stabbed in the shoulder and back of the head with a butcher knife. | Red Devil (Boone) | Yes | First victim of Red Devil, body later found in the Shady Lane House. | |
| 4 | 7 | Tiffany DeSalle | Decapitated by riding lawn mower. | Yes | Her death is the first to be known by the Authorities. | ||
| 5 | 8 | Shondell Washington | Hell Week | Impaled through the throat with a butcher knife. | Partially | Red Devil was seen approaching her from behind with a knife, she is then found dead by Denise. Dead body was later found in the Shady Lane House. | |
| 6 | 9 | Aaron Cohen | Chainsaw | Decapitated with chainsaw. | Yes | Was killed while wearing the new university mascot costume Coney the Cone, body was later found in the Shady Lane house. | |
| 7 | 10 | Mandy Greenwell | Haunted House | Stabbed multiple times with a butcher knife. | Partially | Killed in her trailer, body found at the Shady Lane house. | |
| 8 | 11 | Dodger | Pumpkin Patch | Disemboweled with hedge shears. | Partially | Attacked by Red Devil quickly approaching him from behind and screams for help, but then is gutted with hedge shears and dead body is left lifeless in maze. | |
| 9 | 12 | Caulfield Mount Herman | Seven Minutes in Hell | Axed twice in the stomach, decapitated with axe. | Yes | Died while the Dollar Scholars and Chanel watched. | |
| 10 | 13 | Sam | Suffocated with a sheet of plastic. | Yes | Is the first victim to know the Red Devil's true identity. | ||
| 11 | 14 | Roger | Shot multiple times in the head and face with a nail gun. | Red Devil (Pete) | Yes | Killed right in front of Chanel #5; the Red Devil chooses to let Chanel #5 live. | |
| 12 | 15 | Steven Munsch | Beware of Young Girls | Dismembered and decapitated. | Cathy Munsch | No | Feather is framed and imprisoned for his death, a flashback of Cathy placing Steven's head in the fish tank is seen in Mommie Dearest. |
| 13 | 16 | Jennifer | Mommie Dearest | Stabbed in the head with butcher knife. | Red Devil (Boone) | Yes | Died while making a candle blog video, found on dining table covered in candle wax. |
| 14 | 3 | Mary Mulligan | Drunk driving accident. | Herself | No | Was revealed to Grace by Chanel, along with the fact that Bethany was Grace's mother and she changed her name to Mary Mulligan. | |
| 15 | 17 | Earl Grey | Ghost Stories | Stabbed in the back with a butcher knife. | Red Devil (Boone) | Yes | Boone reveals to Earl that he is the Red Devil before Earl dies. |
| 16 | 18 | Truck Driver | Back hacked and stabbed in the stomach with a machete. | Yes | Was trying to save Chanel #5 from getting killed by the Red Devil. | ||
| 17 | 19 | Boone Clemens | Stabbed in the chest with an army knife. | Red Devil (Pete) | Yes | Pete chose to murder Boone over Gigi because Boone was the muscle of the operation, and he thought that killing Boone would stop the murders. | |
| 18 | 20 | Gigi Caldwell | Thanksgiving | Decapitated with electric carving knife. | Red Devil (Hester Ulrich) | No | The Red Devil removes the turkey from the serving platter replacing it with Gigi's head which is then revealed to the dinner attendees at Kappa. |
| 19 | 21 | Mall Cop | Black Friday | Shot in the forehead with a crossbow. | Red Devil (Pete) | Yes | Killed during the Red Devil's attack at the mall. |
| 20 | 2 | Amy Meyer | Killed herself with laxatives. | Herself | No | Was revealed to Grace by Pete Martínez. | |
| 21 | 22 | Pete Martínez | Dorkus | Stabbed in the back of neck and chest with a knife. | Red Devil (Hester) | Yes | Killed by the Red Devil before he could reveal who it was to Grace Gardner. |
| 22 | 23 | Zak | Blown up by dynamite. | Yes | The Red Devil strapped a bomb to him, then forced him to go inside the Kappa house wearing the RD costume before it detonated. | ||
| 23 | 4 | Original Red Devil mascot | The Final Girl(s) | Stabbed repeatedly in the chest and stomach with a butcher knife. (flashback) |
Gigi Caldwell | Yes | Killed for the mascot costume. |
| # (episode) | # (chronological) | Name | Episode | Cause of Death | Killer | On-Screen | Notes |
| 1 | 1 | Bill | Scream Again | Sedated and thrown into the swamp. (flashback) |
Dr. Mike | Yes | First death we see on-screen in Season Two; sets off a chain of events within the hospital. |
| 2 | 8 | Catherine Hobart | Decapitated with a machete. | Green Meanie (Cassidy) | Yes | Chanel #5 was indirectly responsible for her death by locking her in the bathtub. | |
| 3 | 2 | Doctor #1 (Mets 17 Costume) | Warts and All | Throat slit by a machete as it was being thrown into Doctor #2. (flashback) |
Green Meanie (Jane's brother) | Yes | Murdered during a Halloween massacre at Our Lady of Perpetual Suffering in 1986. |
| 4 | 3 | Doctor #2 (Mets 6 Costume) | Machete thrown into stomach. (flashback) |
Yes | |||
| 5 | 4 | Doctor #3 (Mets 18 Costume) | Chopped in the head with a machete. (flashback) |
Partially | |||
| 6 | 5 | Dr. Mike | Impaled through the stomach with a machete. (flashback) |
Yes | |||
| 7 | 6 | Nurse Thomas | Machete thrown in her back. (flashback) |
Yes | |||
| 8 | 7 | Squash Opponent | Stabbed in the back with a knife extended from a squash racket. (flashback) |
Marshall Winthrop | Yes | One of the 600 opponents Winthrop murdered. | |
| 9 | 9 | Tyler | Eyes, chest, and stomach seared by medical lasers and throat slit with a scalpel. | Green Meanie (Cassidy) | Yes | The laser was supposed to be used to cure his disease, but instead was used to kill him. | |
| 10 | 10 | Randal | Handidates | Sliced three times in the chest and twice in the arms with a scythe. | Yes | He initially thought that the Green Meanie was a trick by the hospital staff to scare him, body was never seen again after death. | |
| 11 | 11 | Sheila Baumgartner | Scythe thrown into her neck, decapitating her. | Green Meanie (Wes) | Yes | Before her death, she already contacted the local news about her treatment at the hospital. | |
| 12 | 17 | Chad Radwell | Stabbed in the throat and fell through the ceiling to his death. | Wes Gardner | No | His body landed directly on the altar at his wedding with Chanel. | |
| 13 | 12 | Brad Radwell | Halloween Blues | Died in a plane crash on their way to stop Chad and Chanel's wedding. | None | No | Was revealed by a lawyer who was dealing with Chad's testament. |
| 14 | 13 | Bunny Radwell | |||||
| 15 | 14 | Muffy Radwell | |||||
| 16 | 15 | Tad Radwell | |||||
| 17 | 16 | Thad Radwell | |||||
| 18 | 18 | Tristan St. Pierre | Chanel Pour Homme-Icide | Sliced in half with a machete. | Green Meanie (Cassidy) | No | Attacked off-screen by the Green Meanie who was seen behind the door while Chanel #8 is looking for her gift. His body was found gutted in a morgue drawer with his intestines spilling out by the Chanels. |
| 19 | 19 | Chanel #11 | Eleventh finger cut off and stabbed through the stomach with 2 machetes. | Yes | Shoved out of the way by Chanel #7 as the rest of the new Chanels were running to escape, causing her to be left behind and killed. | ||
| 20 | 20 | Chanel #9 | Blood Drive | Blood drained from her body using hypodermic needles. | Green Meanie (Cassidy) and Ingrid | Partially | She was donating blood to overcome her fear of needles, but instead they were used to kill her. |
| 21 | 21 | Chanel #10 | The Hand | Strangled with her headphone chord. | Green Meanie (Ingrid) | Yes | Her heart is later used for transplant surgery, saving Anna's life. |
| 22 | 22 | Slade Hornborn | Stabbed in the top of his head with a machete. | Yes | Killed while on the phone with his colleague, talking about a potential scandal at the C.U.R.E. Institute. | ||
| 23 | 23 | Chamberlain Jackson | Rapunzel, Rapunzel | Stabbed twice in the sternum with a kitchen knife. | Wes Gardner | Yes | Killed so he couldn't tell anyone about Wes' involvement in the Green Meanie killings. |
| 24 | 24 | Marguerite Honeywell | Lovin the D | Asphyxiated with a noose. | Green Meanie (Wes) | Yes | She was lured in with snickerdoodles, as Wes dropped a noose down from the ceiling, causing him to almost get a hernia from lifting up her dead-weight. |
| 25 | 25 | Dr. Scarlett Lovin | Drank from a poisoned coffee cup. | Wes Gardner | Yes | The poisoned coffee was originally intended for Chanel, but Scarlett grabbed the wrong cup by accident. | |
| 26 | 26 | Wes Gardner | Submerged into a tub of hot oil, frying his entire body. | Himself | Yes | Cassidy and Ingrid set up the bath as a means to kill him, but instead he initiated the fall into the oil, thus killing himself. | |
| 27 | 27 | Jane Hollis | Drain the Swamp | Shot in the chest with a pistol. | Ingrid Hoffel | Yes | Killed after having a change of heart and trying to convince Ingrid to stop the murder streak. |
| 28 | 28 | Dr. Cassidy Cascade | Machete thrown into his sternum. | Ingrid Hoffel | Yes | The machete was originally thrown in Chanel #3's direction, but Cassidy jumped in front of her, thus saving her life. | |
| 29 | 29 | Ingrid Marie Hoffel | Drowned in the rancid swamp. | None | Yes | Ingrid accidentally fell into the swamp while fleeing the hospital, and although Cathy tried to save her, she was unsuccessful. |
On-screen
| Key | Total |
| Yes | 35 |
| No | 12 |
| Partially | 5 |